Surfactants in Liposomes for Targeted Drug Delivery

Liposome is colloidal, vesicular structures capable of targeting to specific sites. Evans blue dye (hydrophilic dye) were formulated in liposomes using phosphatidyl choline, cholesterol and those liposomes were modified using surfactants surfactants span 20 , span 40 , span 80 or tween 80 at various molar ratio and optimized for its stable vesicular formation. The particle size and FTIR analysis were performed for those formulations. Invivo studies were performed using those surfactant modified liposomes containing a biological marker-Evans blue dye to study the formulation penetrating power to brain. Span 80 and tween 80 combination of molar ratio 2:1 was efficient in modifying the liposomes towards delivering the dye to brain bypassing blood brain barrier than other surfactant modification of liposomes and the liposomes without surfactant..